Long-term sequelae from acute kidney injury: potential mechanisms for the observed poor renal outcomes
M Varrier, LG Forni, M Ostermann - Annual Update in Intensive Care and …, 2015 - Springer
M Varrier, LG Forni, M Ostermann
Annual Update in Intensive Care and Emergency Medicine 2015, 2015•SpringerRenal disease is a global phenomenon with the incidence of both acute and chronic renal
insufficiency continuing to rise [1, 2]. Acute kidney injury (AKI) is a known independent
predictor of hospital mortality despite its multifactorial nature. After an episode of AKI, there
are four potential outcomes [3]: It was previously assumed that those who recovered kidney
function after an episode of AKI were faced with a relatively benign course with favorable
outcomes. However, there is now increasing concern that this is not neccesarily the case …
insufficiency continuing to rise [1, 2]. Acute kidney injury (AKI) is a known independent
predictor of hospital mortality despite its multifactorial nature. After an episode of AKI, there
are four potential outcomes [3]: It was previously assumed that those who recovered kidney
function after an episode of AKI were faced with a relatively benign course with favorable
outcomes. However, there is now increasing concern that this is not neccesarily the case …
Abstract
Renal disease is a global phenomenon with the incidence of both acute and chronic renal insufficiency continuing to rise [1, 2]. Acute kidney injury (AKI) is a known independent predictor of hospital mortality despite its multifactorial nature. After an episode of AKI, there are four potential outcomes [3]:
It was previously assumed that those who recovered kidney function after an episode of AKI were faced with a relatively benign course with favorable outcomes. However, there is now increasing concern that this is not neccesarily the case and these individuals may be at risk of poor long-term outcomes through the development of CKD (including ESRF), further episodes of AKI and an increased risk of premature death. In the following review, we will describe the main pathogenetic links between AKI and CKD and introduce some potential key players.
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